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As the United States opens the door to broad eligibility to COVID-19 vaccines, questions still loom about long-term efforts to contain the pandemic globally and prepare for viral adaptations. Immunologists at the University of Pennsylvania are working to understand the way people respond to COVID-19 vaccines and the lessons that may provide about how to control the spread of variants around the world. People who have already recovered from COVID-19 are showing signs of robust protection from the coronavirus and its variants after just one dose of the Pfizer or Moderna vaccines, according to a new Penn study published in Science NEWSThe gender vaccine gap More women than men are getting COVID-19 shotsPhilly makes all adults 16 and older eligible for COVID-19 vaccineThe variant is spreading rapidly, sparking debates about the vaccination rollout For people who have never had COVID-19, a full immune response isn't realized until after receiving the second vaccine dose. The small study examines the underlying immunobiology of mRNA vaccines, which give the body instructions to build proteins and induce a protective antibody response. Antibodies provide rapid immunity, but just as importantly, mRNA vaccines encourage the formation of memory B cells. This is what gives the body a long-term blueprint to fight off future changes in the virus. "Antibodies are important and we understand this concept now of antibodies being what protects you," said E. John Wherry, director of the Penn Institute of Immunobiology. "But memory B cells are the actual cells in the immune system that are kind of like precursors. When they get activated, they become the antibody factors. They're kept around as a reserve capacity to help protect you if the antibodies that you have don't work well enough, and also to be the substrate to make new kinds of antibodies in the future. These mRNA vaccines induce a really good memory B cell response." The Penn study looked at mRNA vaccine responses in 44 healthy participants, including 11 who had previously recovered from a COVID-19 infection. All of the participants received either the Pfizer or Moderna vaccine and blood samples were collected for deep immune analyses four times — before and after each vaccine dose. Wherry, the study's senior author, described the different responses between people who had never had COVID-19 and those who had recovered from an infection. Though the vaccines produced high and consistent levels of antibodies in 95% of those who received them, people who were previously infected had a more complete response after just one shot, likely because of the primary response they had to the infection. That primary response doesn't appear to be sufficient on its own for long-term protection without a vaccine, however. People who had a mild or asymptomatic COVID-19 infection in the past may only have low antibody levels, which may not be as effective as the vaccine at neutralizing the variant viruses that have become increasingly prevalent. In part, that's because a past infection may not produce high levels of immunological memory. "What we know from the data that's out there is that people who recover from natural infection have a wide range of immune responses," Wherry said. Vaccination ensures a more thorough and long-lasting response, one that accounts for the natural ability viruses have to undermine the body's creation of memory B cells. This is where the mRNA vaccines make the difference, focusing the body's resources on the spike protein of the virus and its variants. "The spike proteins of viruses do this really important thing in that they allow the virus to fuse with your cell," Wherry said. "To do that, this protein is like a spring-loaded weapon. When it binds, it snaps into a new position, and that new position is actually what's being expressed in the vaccines. That allows your immune response to focus on this key part of the virus that's normally hidden. That's the exact part that's needed to actually protect you."'Everyone has good responses' Notably, the study cohort that did not previously have COVID-19 needed both doses of the mRNA vaccine in order to develop a strong memory B cell response. The people in this "COVID naive" group who had systemic side effects after receiving one dose of the vaccine — including fever, chills, headache and fatigue — all showed slightly stronger serum antibody responses than those who had minimal or no side effects. But it took the second dose in order to get a considerable memory B cell response. The study's findings were consistent in the analysis of antibodies against the D614G mutation of the spike protein and in the South African variant of COVID-19. For those who did not have COVID-19, it took a second dose to get a robust enough immunity level against the mutation and variant, whereas those who recovered from COVID-19 had a strong enough antibody response after one don't know whether we're going to need boosters. I'm glad that we're talking about it. Planning for the worst and hoping for the best is always a good strategy. — E. John Wherry, director of the Penn Institute of Immunobiology "Everyone has good responses to the vaccines. They work to protect people against COVID-19," Wherry said. "But for those who may be worried about side effects, they are not necessarily a bad thing — they may actually be an indicator of an even better immune response. Side effects are pretty common. They're something that the drug was designed to do that may just cause initial discomfort. They are telling you that your immune response is working." Wherry said it's important not to get side effects confused with adverse events and use them as a measure of whether COVID-19 vaccines are safe. "There is this claim of side effects and adverse events — side effects being common and on target and OK, adverse events being things that are scary, that are really rare, that are unintended," Wherry said. "For adverse events, we need to study, stop, pause, understand and then adapt. There's a real conflation of those two ideas that I think leads to some lack of confidence." Even the recent pause on the use of the Johnson & Johnson vaccine — which is a traditional "viral vector" vaccine, not an mRNA vaccine — requires a basic examination of risk before mistaking the present caution as grounds for deep distrust. Six women have reported rare and serious blood clots after receiving the single-dose Johnson & Johnson shot. One of them died, while the death of a 21-year-old Ohio man a day after getting vaccinated remains under investigation. "To put the risk of these adverse events in perspective, your chances of dying of COVID, just being an American, are one in 600," Wherry said. "Your chances of having one of these complications of the Johnson & Johnson vaccine are about one in a million. The risk-balance equation here is extremely clear." Building the case that one mRNA vaccine dose may be enough for people who have already had COVID-19 could have ramifications for long-term vaccine distribution strategies. "There may be some settings where we might think about changing policy," Wherry said. "We're going to get to the point of having a lot of the population vaccinated and start to control things, probably before we need to make any policy decisions." Thinking more broadly, the ongoing study in Wherry's lab could influence decisions about how to effectively deploy the vaccine in future hotspots. "To be very clear, this pandemic problem is not going away when the gets to 70% or 80% of people vaccinated. This is a global problem," Wherry said. "We can have Americans vaccinated to a pretty high level, and if we have a pandemic raging in South America or Africa or Asia, it's still going to be a problem here because we're going to have variants driven from other parts of the world that will concern us." Even if enough vaccine supply is developed to meet global needs, the prospect of only using one vaccine dose to safely immunize people with previous infections could make disease control a lot easier. It would mean fewer people have to return for a second dose and tracking progress would become simpler. A versatile, transformative approach One of the more exciting aspects of the study is its findings on strong memory B cell production, which could provide important protection for variants and insights into the development of possible booster shots that are tailored to neutralize them. "We don't know whether we're going to need boosters," Wherry said. "I'm glad that we're talking about it. Planning for the worst and hoping for the best is always a good strategy. These mRNA vaccines induce a really good memory B cell response. As we go to think about boosters that might help with coverage of variants, those memory B cells generated by the vaccine are now our starting point. We don't have to start from square one." The next phase of the study in Wherry's lab will take a larger-scale look at the question of a one- or two-dose regimen in COVID-19-recovered individuals and to see how long the vaccine antibodies last. The lab will also analyze the effect of the vaccine on virus-specific T-cell responses, another facet of the body's protective reaction. Moving forward, Wherry is excited about the potential of mRNA as a tool with wide-ranging applications, both in vaccine science and in the prevention and treatment of other diseases. "They are so easy and quick to make. They're so versatile in what they can do," Wherry said. "I think we've seen a paradigm shift in thinking about infectious disease control, not just in humans but also in animals. The mRNA platform is going to transform the way we do things. In the future, we're going to see this as an inflection point in medicine — not just for vaccines. There are probably other methods that we can think about for mRNA to deliver therapeutics, maybe gene therapy at some point." To get to that point, Wherry said investing in research remains imperative in order to make possible innovations like the COVID-19 vaccines. "We can't overlook fundamental basic science as the foundation that let this happen," Wherry said. "We would not have had a vaccine in a year if there wasn't 20 years of studying what the public would basically think of as esoteric, uninteresting viruses." The study and ongoing research are supported by the National Institutes of Health, the Allen Institute for Immunology, Cancer Research Institute-Mark Foundation Fellowship, Chen Family Research Fund, the Parker Institute for Cancer Immunotherapy, the Penn Center for Research on Coronavirus and Other Emerging Pathogens, the University of Pennsylvania Perelman School of Medicine COVID Fund, the University of Pennsylvania Perelman School of Medicine 21st Century Scholar Fund, and a philanthropic gift from Philadelphia Eagles owner Jeffrey Lurie, 76ers star Joel Embiid and 76ers owners Josh Harris and David Blitzer.
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★★★★☆Classement sur 10 basé sur 7971 1h 57 min. Taille 815 Mégaoctets. Nom de Fichier Believe-Me-Th Translation Hongrois hu-HU - Français fr-FR. Vidéo .SQZ 1440p VHSRipBelieve Me The Abduction of Lisa McVey 2018 Film Entier GratuitDates de sortie 07. mars 1910Scénario Élina V. GorzRevenu $ Kristiyan PaavanaBudget de production $ de production TEProductions, Tele 5 et 3B EntertainmentNationalité Corée du Nord, Corée du SudMusique Japveer AvestaGenres Panégyrique, Drame Social, MaturitéRéalisation Arnaud A. EloiDistributeur Paperny Films, DSBC ProductionActeurs Gwenlli Kaydey, Camélia Fealty, Morneau ShondaPages connexesBelieve Me The Abduction of Lisa McVey DpStream ~ Believe Me The Abduction of Lisa McVey DPStream est le premier index de liens streaming pour ce qui est des films des séries et des mangas dp stream Regarder le meilleur de film streaming HD en version française online Dpstream votre espace de Film en streaming retrouvez tous vos films préférés en streaming les derniers Serie streaming en Français gratuit voir top series 2019 Regarder le film Believe Me The Abduction of Lisa McVey ~ Langue Anglais Believe Me The Abduction of Lisa McVey 30 septembre 2018 From the producer behind “Girl in the Box” and “Girl in the Bunker” comes the disturbing truestory of Lisa McVey who was abducted in 1984 but later released by her abuser only to have pe ople question her storyComment regarder Believe Me The Abduction of Lisa McVey ~ Pouvezvous regarder Believe Me The Abduction of Lisa McVey sur un service de streaming Nous comparons Disney Netflix et Amazon Prime Video pour vous montrer le meilleur endroit où regarder Believe Me The Abduction of Lisa McVey Trouvez où regarder votre film préféré Believe Me The Abduction of Lisa McVey aujourd’hui en streaming avec un essai gratuit™REGARDERBelieve Me The Abduction Of Lisa McVey ~ Believe Me The Abduction of Lisa McVey Streaming Film Gratuit Regarder Film Streaming Préférés complet en VF HD voir Believe Me The Abduction of Lisa Mc™REGARDERBelieve Me The Abduction Of Lisa McVey ~ Believe Me The Abduction of Lisa McVey Film streaming gratuit HD en VF et VOSTFR voir Believe Me The Abduction of Lisa McVey streaming en vf complet gratuiteBelieve Me The Abduction of Lisa McVey 2018 sa prevodom ~ Believe Me The Abduction of Lisa McVey 2018 Jim Donovan Katie Douglas isLisa McVey David James Elliott isSgt Larry Pinkerton Rossif Sutherland isBobby Joe Long Amanda Arcuri isLorrie Chris Owens isDet Wolf Bruno Verdoni isMorris Megan Fahlenbock isBetty Leo Petrus isPortly Man Jamie Robinson isEd Kim Horsman isDiane MartinBelieve Me The Abduction of Lisa McVey AvaxHome ~ Believe Me The Abduction of Lisa McVey AvaxHome From the producer behind “Girl in the Box” and “Girl in the Bunker” comes the disturbing truestory of Lisa McVey who was abducted in 1984 but later released by her abuser only to have people question her storyJean Spinka Series FR ~ Voir Serie Believe Me The Abduction of Lisa McVey en streaming vf vostfr gratuitement 2018 min Si vous êtes une personne passionnée des séries en streaming français vous serez d’accords pour dire que la serie Believe Me The Abduction of Lisa McVey est la meilleure de toutesBelieve Me The Abduction of Lisa McVey streamen Netflix ~ Believe Me The Abduction of Lisa McVey Streaming Overzicht De 17jarige Lisa McVey wil op een avond zelfmoord plegen Ze wordt echter gekidnapt en zet alles op alles om te overleven Lisa weet haar ontvoerder echter om te praten en wordt vrijgelaten Ze keert terug naar huis maar bijna niemand gelooft haar verhaal De enige die haar gelooft is een rechercheur die denkt dat Lisa ontvoerd werd Miss Alvena OReilly DVM ~ Voir Serie Believe Me The Abduction of Lisa McVey en streaming vf vostfr gratuitement 2018 min Si vous êtes une personne passionnée des séries en streaming français vous serez d’accords pour dire que la serie Believe Me The Abduction of Lisa McVey est la meilleure de toutes
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The live Bitgert price today is $ USD with a 24-hour trading volume of $6,868,043 USD. We update our BRISE to USD price in real-time. Bitgert is up in the last 24 hours. The current CoinMarketCap ranking is 2742, with a live market cap of not available. The circulating supply is not available and a max. supply of 1,000,000,000,000,000 BRISE you would like to know where to buy Bitgert at the current rate, the top cryptocurrency exchanges for trading in Bitgert stock are currently MEXC, KuCoin, and BitMart. You can find others listed on our crypto exchanges Is Bitgert BRISE?Bitgert BRISE is a crypto engineering project launched in July 2021 that specializes in blockchain products and auditing solutions. Initially, Bitgert was built on BNB Chain and used BNB, its native token, to pay rewards. However one of the most significant Bitgert developments was presented in 2022 the BRC20 blockchain. It offers near-zero gas fees and high speed cross-chain transactions. More specifically, the gas fee is $ per transaction, while the supported throughput is up to 100,000 list of Bitgert products also includes Audit Solutions with Leaderboard Support, BRISE dApp Wallet, BRISE staking, BRISE Swap, and Bitgert offers an alternative to the popular DEX platform PancakeSwap. BRISE Wallet DApp is the main gateway to the ecosystem, allowing users to securely send, receive, store and exchange various crypto is Bitgert's native token, allowing investors to benefit from staking and earning rewards in smart contracts on Brise Chain feature a buyback mechanism. To be more precise, Bitgert directs 5% of every transaction fee for buyback, 3% for marketing and 4% for staking rewards. According to the team, buyback is meant to support the price of BRISE token making it a deflationary claims to have a real use case with becoming the global payment system and is applied as a peer-to-peer P2P service in the BRISE dApp Wallet. Thus, buyers and sellers interact directly, without the participation of a third party, through the P2P service, and transactions are carried out quickly, securely and with zero Are the Founders of Bitgert?The Bitgert project started its journey in the summer of 2021, the whitepaper indicates that the platform was launched in July. This entire time the dev team worked anonymously, but it was announced that they are planning to reveal their identities when the time comes. So far, no specific deadlines have been published, but one thing remains certain - doxxing the team should positively affect the project’s reputation and the price of BRISE, since the move can lead to building trust from the crypto community and generating more interest among investors. In addition, according to the team, in the short term and before the exchange launch, Bitgert will be registered as a legal entity, presumably in the Cayman Makes Bitgert Unique?Bitgert BRISE uses a DeFi protocol and was deployed on BNB Chain. The rapidly growing ecosystem covers areas such as DeFi, NFT, Web and Metaverse. The Bitgert ecosystem introduces the following productsBitgert Chain is an EVM-compatible blockchain with gas fees as low as $ per transaction;BRISE dApp Wallet with BRC20/ERC20/BEP20 support for Android and iOS. The multi-currency crypto wallet allows users to send, receive, store and swap various crypto assets in a safe and secure manner;BRISE Swap is a fast and cheap decentralized exchange DEX powered by BNB Chain. BRISE Swap positions itself as an alternative to the PancakeSwap platform - a decentralized exchange for swapping BEP20 tokens on BNB Chain;BRISE Staking. The program allows BRISE holders to stake their tokens and earn BUSD in reward;Audit Solutions with Leaderboard Support is responsible for security of the blockchain. Bitgert Audit uses cutting-edge AI Technology and Manual code review to protect smart contracts;Bitgert Bridge. The product is still under development, however, in the near future, the technology will help transfer assets from BNB Chain to Bitgert PagesRead about Cardano ADA and Centcex CENX.Learn more about PancakeSwap CAKE.The latest data about BNB BNB.What are Peer-to-Peer P2P networks? Find out with CMC up on crypto terms with our out our DeFi Many Bitgert BRISE Coins Are There in Circulation?BRISE token functions as an intermediary in a peer-to-peer P2P service for payments in local currency, with the use the BRISE Wallet dApp, featuring fast and secure transactions and zero transaction fees. In this scenario, a seller and a buyer can cooperate directly with each other, without the need for token is endowed with a buyback mechanism. How does it work a 5% buyback tax is charged on each transaction and stored inside a smart contract. If the sale has taken place, then part of the tax paid is allocated to the automatic token purchase from the liquidity pool, with the said tokens being burned immediately afterwards. Advantages price increase buying tokens from the liquidity pool results in new BNB tokens being added to the pool and a decrease in the number of BRISE tokens; the emergence of free BNB tokens; reliability and trust from the Bitgert shares with its investors a 4% commission on every transaction, proportional to their stake and in BUSD tokens. The total tax commission on the network is 12%.The full supply of BRISE tokens of 1,000,000,000,000,000 coins was minted at the platform launch. The distribution is as follows 50% to Initial burn, 38% to Liquidity, 7% to Future development and Marketing, 5% to Dev Is the Bitgert Network Secured?BRISE Chain is relying on a proof-of-staked-authority consensys mechanism for its security. Audit Solutions with Leaderboard Support aims to secure the Bitgert network. The platform provides free auditing to protect equally smart contracts and blockchains. The latest Bitgert Audit was released in August 2021. Where Can You Buy Bitgert BRISE?As of April 2022, users can buy BRISE tokens at several platforms like PancakeSwap V2, MEXC, Hotbit among other CEXs and is a list of the best bitcoin wallets to keep your coins the CMC mobile app to track prices of BRISE or BNB in the CMC blog to increase your knowledge of crypto.
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WatchBelieve Me (2014) Full Movie Online Streaming. Sam (Alex Russell) stands on stage as thousands of fans go wild. Smart, charismatic, handsome, he moves them with his message, and when he calls for donations to his charity, the money pours in. Only thing is, Sam doesn't believe a word he's saying. Just months earlier, Sam was a typical
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UserScore Play Teaser Overview On the night she plans on taking her own life, 17-year-old 'Lisa McVey' is kidnapped and finds herself fighting to stay alive and manages to be a victim of rape. She manages to talk her attacker into releasing her, but when she returns home, no one believes her story except for one detective, who suspects she was abducted by a serial killer. Based on horrifying true events. Jim Donovan Director Christina Welsh Writer There are no offers for Believe Me The Abduction of Lisa McVey. You need to be logged in to continue. Click here to login or here to sign up. Global s focus the search bar p open profile menu esc close an open window ? open keyboard shortcut window On media pages b go back or to parent when applicable e go to edit page On TV season pages → right arrow go to next season ← left arrow go to previous season On TV episode pages → right arrow go to next episode ← left arrow go to previous episode On all image pages a open add image window On all edit pages t open translation selector ctrl+ s submit form On discussion pages n create new discussion w toggle watching status p toggle public/private c toggle close/open a open activity r reply to discussion l go to last reply ctrl+ enter submit your message → right arrow next page ← left arrow previous page
BelieveMe: The Abduction of Lisa McVey: Directed by Jim Donovan. With Katie Douglas, David James Elliott, Rossif Sutherland, Amanda Arcuri. On the night she plans on
Why should I go? Feel spirited away in this decommissioned gold mining mountain town, originally built by the Japanese and now a maze of lanes and alleyways with rich history and culture. Founded during the Qing Dynasty, this small town was a relatively isolated village until the discovery of gold during the Japanese occupation in 1893, quickly developing the town due to a gold rush. Many buildings in the town remain unchanged to this day, reflecting the Japanese influence on both architecture and culture on the island. During World War II, the town housed a Japanese prisoner of war camp where captured Allied Force soldiers mainly British were forced to work in the gold mines. After the war, gold mining activities declined, and the town today exists mainly as a tourist destination remembering and celebrating Taiwanese history and culture. How to get there? By Train From Taipei Main Station 台北車站, take the train north to Ruifang Station. After exiting the station and facing the Wellcome supermarket, take a left and walk 200 meters down Mingdeng Road. Next to the police station is a bus station named Local Residents Plaza, 區民廣場 with routes 827 and 788 heading toward Jiufen. Please note that the bus stop next to the police station heads east toward Jiufen, and the bus stop across from the police station heads west toward Taipei. Route 825 provides weekend service only. From here, the bus trip takes roughly 15 minutes, and the fare is NT$15. It is recommended to take bus 1062 back to Taipei and enjoy some time at Raohe Night Market 饒河夜市. By Bus From MRT Zhongxiao Fuxing 忠孝復興, Brown Line BR and Blue Line BL interchange, leave from Exit 2 and from outside Sogo department store take bus route 1062 Keelung Bus to Jinguashi, alight at Jiufen. The ride is about 1 hour and the fare is NT$98. Be sure to get a good seat to enjoy scenic views of Northern Taiwan. Bus 788 is also available from Keelung. A new bus service number 965 is running from Ximen and Beimen near Taipei Main Station out to Ruifang, Jiufen, and Jinguashi, fare NT$90. Newer Post 220 comments
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Notedesutilisateurs Synopsis Dans ce film inspiré de faits réels, une adolescente de Floride se fait kidnapper puis parvient à fuir, mais peine à convaincre sa famille et la police de son calvaire. Jim Donovan Director Christina Welsh Writer Il n'y a actuellement aucune offre pour Believe Me Enlevée par un tueur dans le pays sélectionné. You need to be logged in to continue. Click here to login or here to sign up. Général s Mettre le curseur dans la barre de recherche p Ouvrir le menu du profil esc Fermer une fenêtre ouverte ? Ouvrir la fenêtre des raccourcis clavier Sur les pages des médias b Retour ou vers le parent si faisable e Afficher la page de modification Sur les pages des saisons des émissions télévisées → Afficher la saison suivante flèche droite ← Afficher la saison précédente flèche gauche Sur les pages des épisodes des émissions télévisées → Afficher l'épisode suivant flèche droite ← Afficher l'épisode précédent flèche gauche Sur toutes les pages des images / photos a Ouvrir la fenêtre d'ajout d'image / photo Sur toutes les pages de modifications t Ouvrir le sélecteur de traduction ctrl+ s Envoyer le formulaire Sur les pages des discussions n Créer une nouvelle discussion w Basculer le statut de suivi p Basculer publique / privée c Basculer fermer / ouvrir a Ouvrir l'activité r Répondre à la discussion l Afficher la dernière réponse ctrl+ enter Envoyer votre message → Page suivante flèche droite ← Page précédente flèche gauche
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